Small-cell lung PAL and Coaxial cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and counterproductive.This report presents the case of a 77-year-old Caucasian male with extens
Abstract According to a paper released and submitted to WHO by IARC scientists, there would be 905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths expected as a direct result.Hepatitis B virus (HBV) hepatitis C virus (HCV), and hepatitis D virus (HDV) all play critical roles in the pathogenesis of hepatocellular carcin
Summary: Proper regulation of the cell cycle is essential to safeguard the genomic integrity of embryonic stem cells (ESCs) while maintaining the fast proliferation rate.The pluripotency factor OCT4 has been shown to inhibit CDK1 activation, thus preventing mitotic entry and facilitating the maintenance of genomic integrity.Yet, how ESCs enter mito
General social measures of crime prevention, as a complex of promising Fender Hobbles socio-economic and cultural-educational measures, are aimed at reducing social contradictions in all spheres of public life.These measures should belong to the reasonable economic-organizational, cultural and educational activities of state bodies, enterprises, in